2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Dipeptidyl Peptidase

Dipeptidyl Peptidase

Peptidase

DPP

Dipeptidyl Peptidase

Related Products

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Dipeptidyl Peptidases are widely distributed exopeptidases that possess central role in proteolysis. The dipeptidyl peptidase family, including DPP-IV DPP7, DPP8, DPP9, fibroblast activation protein and others, cleave the peptide bond after the penultimate proline residue and are drug target rich.

DPP-IV (DPP4 or CD26) is a serine protease detected on several immune cells and on epithelial cells of various organs. Besides the membrane-bound enzyme, a catalytically active soluble form is detected in several body fluids. Both variants cleave off dipeptides from the N-termini of various chemokines, neuropeptides, and hormones. DPP IV plays a key role in immune-regulation, inflammation, oxidative stress, cell adhesion, and apoptosis by targeting different substrates. DPP IV inhibitors are commonly used as hypoglycemic agents.

DPP8 and DPP9 show DPPIV-like activity and share a very high-sequence similarity to each other. DPP8 and DPP9 are intracellular N-terminal dipeptidyl peptidases (preferentially postproline) associated with pathophysiological roles in immune response and cancer biology.

Dipeptidyl Peptidase Isoform Specific Products:

Dipeptidyl Peptidase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-13749
    Sitagliptin
    		Inhibitor 99.75%
    Sitagliptin (MK-0431) is a potent and orally active inhibitor of DPP4 with an IC50 of 19 nM in Caco-2 cell extracts.
    Sitagliptin
  • HY-13233A
    Talabostat mesylate
    		Inhibitor 98.35%
    Talabostat mesylate (Val-boroPro mesylate; PT100 mesylate) is an orally active and nonselective dipeptidyl peptidase IV (DPP-IV) inhibitor (IC50 < 4 nM; Ki = 0.18 nM) and the inhibitor of fibroblast activation protein (FAP) (IC50 = 560 nM), inhibits DPP8/9 (IC50 = 4/11 nM; Ki = 1.5/0.76 nM), quiescent cell proline dipeptidase (QPP) (IC50 = 310 nM), DPP2, and some other DASH family enzymes. Antineoplastic and hematopoiesis- stimulating activities.
    Talabostat mesylate
  • HY-15695
    Puromycin aminonucleoside
    		Inhibitor 99.86%
    Puromycin aminonucleoside (NSC 3056) is the aminonucleoside portion of the antibiotic puromycin, and used in nephrosis animal models. Puromycin aminonucleoside induces apoptosis. Puromycin aminonucleoside is a reversible inhibitor of dipeptidyl peptidase II and cytosol alanyl aminopeptidase. Puromycin aminonucleoside induces secretion of cell migrasome.
    Puromycin aminonucleoside
  • HY-10284
    Linagliptin
    		Inhibitor 99.91%
    Linagliptin is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM.
    Linagliptin
  • HY-101056
    Brensocatib
    		Inhibitor 99.88%
    Brensocatib (AZD7986) is an oral dipeptidyl peptidase 1 (DPP1) inhibitor with pIC50s of 6.85, 7.6, 7.7, 7.8, and 7.8 in human, mouse, rat, dog and rabbit, respectively.
    Brensocatib
  • HY-I0786
    (2S,4R)-Teneligliptin
    		Inhibitor
    (2S,4R)-Teneligliptin is a selective inhibitor of dipeptidyl peptidase IV (DPP-4). (2S,4R)-Teneligliptin increases the plasma concentration of active glucagon-like peptide-1 (GLP-1), which promotes insulin secretion in response to elevated blood glucose levels, exerting hypoglycemic activity. (2S,4R)-Teneligliptin is promising for research of type 2 diabetes.
    (2S,4R)-Teneligliptin
  • HY-P4558A
    H-Pro-Lys-OH TFA
    		Substrate
    H-Pro-Lys-OH TFA is a dipeptide containing proline and lysine, which can serve as a substrate for iminodipeptidase (prolinase). H-Pro-Lys-OH TFA can also be used for the synthesis of polypeptides.
    H-Pro-Lys-OH TFA
  • HY-170569
    Cetagliptin
    		Inhibitor
    Cetagliptin is an orally active inhibitor for dipeptidyl peptidase 4 (DPP-4) and CYP2D6 (IC50 of 6 µM). Cetagliptin is a substrate for P-glycoprotein. Cetagliptin reduces the GLP-1 degradation, maintains the level of postprandial blood sugar, and can be used in type 2 diabetes mellitus research.
    Cetagliptin
  • HY-13749A
    Sitagliptin phosphate
    		Inhibitor 99.79%
    Sitagliptin phosphate (MK-0431 phosphate) is a potent inhibitor of DPP4 with an IC50 of 19 nM in Caco-2 cell extracts.
    Sitagliptin phosphate
  • HY-111174
    Diprotin A
    		Inhibitor 99.58%
    Diprotin A (Ile-Pro-Ile) is an inhibitor of dipeptidyl peptidase IV (DPP-IV).
    Diprotin A
  • HY-14291
    Vildagliptin
    		Inhibitor 99.93%
    Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity.
    Vildagliptin
  • HY-116304
    1G244
    		Inhibitor 98.50%
    1G244 is a potent DPP8/9 inhibitor with IC50s of 12 nM and 84 nM, respectively. 1G244 does not inhibit DPPIV and DPPII. 1G244 induces apoptosis in multiple myeloma cells and has anti-myeloma effects.
    1G244
  • HY-15981
    Omarigliptin
    		Inhibitor 99.96%
    Omarigliptin (MK-3102) is a potent, selective, orally active and cross the blood-brain barrier dipeptidyl peptidase 4 (DPP-4) inhibitor. Omarigliptin shows anti-parkinsonian activity. Omarigliptin has the neuroprotective effect to improve diabetes-associated cognitive dysfunction.
    Omarigliptin
  • HY-10285
    Saxagliptin
    		Inhibitor 99.96%
    Saxagliptin (BMS-477118) is a potent, selective, reversible, competitive and orally active dipeptidyl peptidase-4 (DPP-4) (Ki = 0.6-1.3 nM) inhibitor. Saxagliptin has the peotential for type 2 diabetes mellitus research.
    Saxagliptin
  • HY-14806
    Teneligliptin
    		Inhibitor 99.79%
    Teneligliptin (MP-513) hydrobromide hydrate is an orally active and selective dipeptidyl peptidase 4 (DPP-4) inhibitor (IC50s: 0.37 and 0.29 nM for the human and rat DPP-4, respectively). Teneligliptin hydrobromide hydrate improves blood glucose levels and can be used in researches related to type 2 diabetes mellitus.
    Teneligliptin
  • HY-A0023
    Alogliptin Benzoate
    		Inhibitor 99.99%
    Alogliptin Benzoate (SYR-322) is a potent, selective and orally active inhibitor of DPP-4 with an IC50 of <10 nM, and exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9. Alogliptin Benzoate can be used for the research of type 2 diabetes.
    Alogliptin Benzoate
  • HY-13749B
    Sitagliptin phosphate monohydrate
    		Inhibitor 99.49%
    Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) is a potent inhibitor of DPP4 with an IC50 of 19 nM in Caco-2 cell extracts.
    Sitagliptin phosphate monohydrate
  • HY-A0023A
    Alogliptin
    		Inhibitor 99.85%
    Alogliptin (SYR-322 free base) is a potent, selective and orally active inhibitor of DPP-4 with an IC50 of <10 nM, and exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9. Alogliptin can be used for the research of type 2 diabetes.
    Alogliptin
  • HY-B0422
    Nateglinide
    		Inhibitor 99.95%
    Nateglinide, a D-phenylalanine derivative, is an orally active and short-acting insulinotropic agent and a DPP IV inhibitor. Nateglinide inhibits ATP-sensitive K+ channels in pancreatic β-cells. Nateglinide is used for the treatment of type 2 (non-insulin-dependent) diabetes mellitus.
    Nateglinide
  • HY-15408
    Trelagliptin
    		Inhibitor 99.54%
    Trelagliptin (SYR-472) is a potent, orally active and highly selective DPP-4 inhibitor with an IC50 of 4 nM. Trelagliptin succinate improves glycemic control in vivo and can be used for the study of type 2 diabetes mellitus (T2DM).
    Trelagliptin
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity
Dipeptidyl Peptidase Isoform Comparison

DPP-1

DPP-2

DPP-4

DPP-8

DPP-9

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Dipeptidyl Peptidase Inhibitors
Product NameDPP-1DPP-2DPP-4DPP-8DPP-9Purity    
Sitagliptin  
DPP-4
  99.75%
Talabostat mesylate  
DPP-4
  98.35%
Puromycin aminonucleoside 
DPP-2
   99.86%
Linagliptin  
DPP-4
  99.91%
Brensocatib
DPP-1
    99.88%
Sitagliptin phosphate  
DPP-4
  99.79%
Diprotin A  
DPP-4
  99.58%
Vildagliptin  
DPP-4
  99.93%
1G244  
DPP-4
  98.50%
Omarigliptin  
DPP-4
  99.96%
Saxagliptin  
DPP-4
  99.96%
Teneligliptin  
DPP-4
  99.79%
Alogliptin Benzoate  
DPP-4
  99.99%
Sitagliptin phosphate monohydrate  
DPP-4
  99.49%
Alogliptin  
DPP-4
  99.85%
Nateglinide  
DPP-4
  99.95%
Trelagliptin  
DPP-4
  99.54%
Teneligliptin hydrobromide  
DPP-4
  99.99%
Anagliptin  
DPP-4, IC50: 3.8 nM
DPP-8, IC50: 68 nM
DPP-9, IC50: 60 nM
99.91%
Trelagliptin succinate  
DPP-4
  99.96%
γ-Glu-Tyr  
DPP-4, IC50: 6.77 mM
  98.35%
K579  
DPP-4
  99.19%
Diprotin A TFA  
DPP-4
  99.62%
Evogliptin tartrate  
DPP-4
  99.71%
Saxagliptin hydrochloride  
DPP-4
  99.71%
Sitagliptin-d4 phosphate  
DPP-4
  99.48%
Retagliptin phosphate  
DPP-4
  99.89%
TS-021 free base  
DPP-4
  99.29%
Gosogliptin  
DPP-4
  99.83%
Timosaponin A1  
DPP-4, IC50: 33.25 μM
  99.70%
Sitagliptin fenilalanil  
DPP-4
  99.76%
Saxagliptin hydrate  
DPP-4
  ≥99.0%
Cofrogliptin  
DPP-4
  99.07%
Azaleatin  
DPP-4
  98.80%
NZ-97  
DPP-4, IC50: 18 nM
DPP-8, IC50: 1258 nM
DPP-9, IC50: 561 nM
99.43%
Linagliptin-d4  
DPP-4
  99.62%
Gemigliptin  
DPP-4
  
Vildagliptin dihydrate  
DPP-4
  
Talabostat  
DPP-4
  
Fotagliptin benzoate  
DPP-4, IC50: 22.7 nM
  99.19%
Alogliptin-d3  
DPP-4
  99.61%
NDMC101  
DPP-4
  99.91%
HAEGT  
DPP-4
  98.86%
Alogliptin-13C,d3  
DPP-4
  
Teneligliptin-d8  
DPP-4
  
Nateglinide-d5  
DPP-4
  ≥98.0%
Prodipine hydrochloride  
DPP-4
  99.84%
Fotagliptin  
DPP-4, IC50: 2.27 nM
  99.05%
Anagliptin hydrochloride  
DPP-4, IC50: 3.8 nM
DPP-8, IC50: 68 nM
DPP-9, IC50: 60 nM
(S)-Sitagliptin phosphate  
DPP-4
  
PB01  
DPP-4, IC50: 15.66 nM
  
MPO-IN-6  
DPP-4, IC50: 31.02 μM
  
Vildagliptin-d7  
DPP-4
  
DPP-4/GPR119 modulator 1  
DPP-4
  
Linagliptin-13C,d3  
DPP-4
  
DPP-4-IN-3  
DPP-4
  
DPP-8/9 probe-1  
DPP-4, IC50: .44 μM ([1])
DPP-8, IC50: 210 nM ([1])
DPP-9, IC50: 15 nM ([1])
AMG-222  
DPP-4
  
DPP-4-IN-1  
DPP-4, IC50: 49 nM
  
DPP8/9-IN-1   
DPP-8, IC50: 14 nM
DPP-9, IC50: 298 nM
DPP-4-IN-10  
DPP-4
  
DPP-4-IN-11  
DPP-4, IC50: 2.75 μM
  
DPP-4-IN-2  
DPP-4, IC50: 79 nM
  
Carmegliptin  
DPP-4
  
DPP-4/GPR119 modulator 2  
DPP-4
  
Propyl-GSK-2793660
DPP-1
    
Teneligliptin-d4  
DPP-4
  
P32/98 hemifumarate  
DPP-4, Ki: 130 nM
  
Propyl-GSK-2793660 hydrochloride
DPP-1
    
SGP8  
DPP-4
  
DPP-4-IN-12  
DPP-4, IC50: 2 nM
  
DPP-4-IN-8  
DPP-4, Ki: 0.96 μM
  
VAMP  
DPP-4, IC50: 1 μM
DPP-4, Kd: 6.89 μM
  
DPP-4-IN-15  
DPP-4, IC50: 8.24 μM
  
Epostatin 
DPP-2
   
H-Gly-Pro-Hyp-OH acetate  
DPP-4, IC50: 2.51 mM
  
Lupinalbin A  
DPP-4, IC50: 45.2 μM
  
Vildagliptin-d3  
DPP-4
  
HTS13517  
DPP-4, IC50: 10.73 μM
  
TS-021  
DPP-4